Lisinopril for Renal Protection in Postpartum Preeclamptic Women

• Status: Withdrawn
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

There may be a role for Lisinopril in improving renal protection in post-partum women who had preeclampsia during pregnancy. The aim of this study is to determine whether routine initiation of Lisinopril after delivery, in women who had preeclampsia while they were pregnant, can control high blood pressure and improve kidney function.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eastern Virginia Medical School
• Treatments: Lisinopril

Criteria

Inclusion Criteria:

• Women 18 to 50 yrs of age with mild or severe preeclampsia diagnosed using criteria (listed below) set forth by the American College of Obstetrics and Gynecology (ACOG) Criteria. (Note; women who become eclamptic will be included in the study.)

• Blood Pressure of 140 mmHg systolic or greater or 90 mmHg diastolic or higher that occurs after 20 weeks' gestational age in a woman with previously normal blood pressure

• Proteinuria defined as 0.3 g protein or higher in a 24 hour urine specimen.

• Preeclampsia was considered severe when any of the following were present:

1. Blood pressure of 160 mmHg systolic of higher or 110 mg Hg diastolic or higher on two occasions at least 6 hours apart while the patient is on bed rest

2. Proteinuria of 5 grams of higher in a 24-hour urine specimen of 3+ or greater on two random urine samples collected at least 4 hours apart

3. Oliguria of less than 500cc in 24 hours

4. Cerebral of visual disturbances

5. Pulmonary edema or cyanosis

6. Epigastric or right upper quadrant pain

7. Impaired liver function, thrombocytopenia

8. Fetal growth restriction.

Exclusion Criteria:

• Women with:

• Prior hypersensitivity (allergic reaction) to Lisinopril or ACE Inhibitors

• Pre-gestational chronic hypertension

• Pre-gestational diabetes

• Rheumatologic disorders (i.e., systemic lupus erythematosus, scleroderma)

• Multiple gestations for present pregnancy

• Patients who declined birth control postpartum

• Patient who has been on an Ace-inhibitor within 6 months prior to pregnancy

• Cardiac problems like; Aortic stenosis or Hypertrophic cardiomyopathy

• Severe kidney disease

• Myocardial infarction within the past 6 months

• Taking any of the prohibited medications listed in section VI

• Breast feeding

• Prisoners will not be included in the study due to difficulty in tracking their pregnancy care being provided at the prison centers