Lithium Effects on Reward Processing and Reappraisal in Healthy Volunteers
Status:
Completed
Trial end date:
2012-09-04
Target enrollment:
Participant gender:
Summary
Bipolar disorder has been associated with blunted activity in regions associated with
emotional processing, such as striatal activity during reward anticipation as well as
prefrontal activity during reappraisal. Lithium is the most effective treatment in bipolar
disorder. Neurochemical and molecular basis of lithium is well known, but how this translates
to mood stabilisation is not understood. This study is designed to address how lithium
influences reward and emotion regulation processes in humans.