Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia

• Status: Completed
• Trial end date: 2013-02-01
• Target enrollment: 0
• Participant gender: All

Summary

In this multicenter, randomised, placebo-controlled, double-blind trial, hyperalgesia area around the scarce following colorectal laparoscopic surgery (piece removal) will be assessed in 3 groups of patients : group 1: continuous ropivacaine preperitoneal infusion, group 2 : intravenous lidocaine infusion, or group 3 : control group without local anesthetics. All patients will receive parenteral analgesia combining acetaminophen and morphine.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Acetaminophen; Anesthetics; Anesthetics, Local; Lidocaine; Morphine; Ropivacaine

Criteria

Inclusion Criteria:

• Age 18 to 80

• ASA status 1 - 3

• Colorectal laparoscopic surgery with piece removal

• French speaking

• Written informed consent

Exclusion Criteria:

• laparoscopy without colorectal extraction

• chronic pain

• analgesic consumption during the 24 hours previous to the surgery

• morphine and LA intolerance

• drug addiction

• inflammatory bowel disease

• general inflammatory disease

• sepsis

• anemia < 10 gr/dl

• liver or renal or cardiac insufficiency

• uncontrolled diabetes

• preoperative consumption of opiate/corticosteroid/beta-blockers, and anti-arrhythmic drugs, MAOIs, neuroleptics.

• preoperative consumption of NSAIDs excluding aspirin referred cardiology