Local Anesthetic Infusion and Sternotomy

• Status: Terminated
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Cardiac surgery often induces acute postoperative pain and moreover chronic dysesthesia frequently occur long-term after sternotomy. The high doses of intraoperative opioïds are well known to enhance postoperative hyperalgesia (HA) and a perioperative local anesthetic agent infusion is one of the therapeutic strategies used to limit this phenomena. The aim of this study was to evaluate the effectiveness of a continuous Ropivacaïne sternal infusion compared with a saline serum infusion to limit postoperative HA, pain and morphine consumption (M) after sternotomy in cardiac surgery.

This strategy could lead to lower postoperative morphine consumption and opioïd induced hyperalgesia.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Bordeaux
• Treatments: Anesthetics; Anesthetics, Local; Ropivacaine

Criteria

Inclusion Criteria:

• Patients aged from 50 to 75 years old

• ASA score : 1-3

• Cardiac surgery with median sternotomy for:

• single valve replacement, Bentall, Bahnson, Tyrone David procedure

• single or multiple Cardiac Artery Bypass Grafting (CABG)

• combined surgery (valve replacement + CABG)

• without predicted risk of postoperative complication

• Informed consent obtained from the patient

• Patient beneficiating of social insurance

Exclusion Criteria:

• patient refusal to participate in the study

• Drug or alcohol abuse history

• Analgesic or opioid consumption within the 12 hours preceding the surgery

• Chronic use of analgesic drugs or history of chronic pain

• Disability to understand morphine PCA use

• Allergy to ropivacaine or other local anaesthesia

• Patient treated by fluvoxamine or enoxamine

• Patient suffering for liver insufficiency (child score >A)

• Patient with major preoperative hypovolemia