Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Between 2008 and 2012 the investigators performed a single-center randomized double-blind
placebo-controlled trial to assess the efficacy of local injection of two different doses of
methylprednisolone (80 mg and 40 mg) in patients with carpal tunnel syndrome (CTS), aged 18
to 70 years, not previously treated with steroid injection. The primary outcomes were change
in the CTS symptom severity score at 10 weeks and rate of carpal tunnel release surgery on
the study hand at 1 year. In the trial 111 patients were randomized (37 in each of the 3
groups: 80 mg methylprednisolone, 40 mg methylprednisolone and placebo) and all completed the
1-year follow-up. The investiators plan an extended follow-up 5 to 7 years after injection.