Background Prompt reperfusion with percutaneous coronary intervention (PCI) in the setting of
ST-elevation myocardial infarction (STEMI) improves clinical outcomes through salvage of
myocardial tissue.
Although the use of thrombus aspiration with PCI can result in improved rates of normal
epicardial flow and myocardial perfusion, several unmet needs remain.
Purpose The purpose of this trial will be to evaluate the hypothesis that local delivery of
thrombolytics vs. saline infusion prior to thrombus aspiration and PCI is safe and effective
in patients with STEMI.