Locally Delivered 1% Metformin Gel in the Treatment of Intrabony Defects in Chronic Periodontitis

• Status: Unknown status
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study was designed as a randomized, controlled clinical trial to evaluate the efficacy of 1% MF gel as local drug delivery in adjunct to SRP for the treatment of intrabony defects in chronic periodontitis in comparison with placebo gel.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Government Dental College and Research Institute, Bangalore
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Systemically healthy subjects

• Sites with probing depth (PD) ≥5 mm

• Clinical attachment level (CAL) ≥4 mm

• Vertical bone loss ≥3 mm on intraoral periapical radiographs with no history of periodontal therapy or use of antibiotics in the preceding 6 months were included

Exclusion Criteria:

• Patients with known systemic disease

• Known or suspected allergy to the MF/ biguanide group

• Patients on systemic MF or other oral antidiabetic therapy

• Patients with aggressive periodontitis

• Patients with diabetes

• Use of tobacco in any form

• Alcoholism

• Immunocompromised patients

• Pregnant or lactating females