Locally Delivered Antibiotics for the Treatment of Periodontitis

• Status: Unknown status
• Trial end date: 2020-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The sample consists of patients with moderate to severe periodontitis who will be subjected to machanical therapy in combination to local antibiotics. The participants will be divided into two groups, mechanical therapy with metronidazole hyclate, and mechanical therapy with minocycline hydrochloride. Both antibiotics will be delivered locally as gels. Outcome measures include probing pocket depth and several gingival indices. IL6 will be also measured for all participants.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Riyadh Elm University
• Treatments: Anti-Bacterial Agents; Metronidazole; Minocycline

Criteria

Inclusion Criteria:

• Patients suffering from chronic periodontitis with almost similar probing depth bilaterally (≥

• 6 mm) at the selected sites and exhibiting bleeding on probing Patients with no caries and restorations on the selected teeth

• Patients showing effective individual oral hygiene.

Exclusion Criteria:

Patients presenting with history of intake of local and/or systemic antibiotic therapy for the last 3 months

• Patients with known systemic and debilitating diseases (Muscular Dystrophy)

• Patients presenting with known adverse reactions to any component of the test agent

• Patients on anticoagulant therapy

• Pregnant and lactating females

• Smokers

• Patients in a regular use of mouth wash