Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis
Status:
Completed
Trial end date:
2016-02-01
Target enrollment:
Participant gender:
Summary
Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the
body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a
rate limiting enzyme for cholesterol synthesis. Rosuvastatin (RSV) and atorvastatin (ATV)
have shown to have bone stimulatory and anti-inflammatory effects.. The present study aims to
explore the efficacy of 1.2% RSV and 1.2% ATV gel as a local drug delivery and redelivery
system as an adjunct to scaling and root planing (SRP) for the treatment of degree II
furcation defects.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Government Dental College and Research Institute, Bangalore