Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis
Status:
Completed
Trial end date:
2017-02-01
Target enrollment:
Participant gender:
Summary
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts
differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favorable
effect on alveolar bone.
AloeVera Gel had also been used in dentistry and showed good results.The present study aims
to explore the efficacy of 1% MF gel and aloe vera gel as a local drug delivery system in
adjunct to scaling and root planing (SRP) for the treatment of subjects with chronic
periodontitis (CP) with intrabody defects.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Government Dental College and Research Institute, Bangalore