Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease

• Status: Completed
• Trial end date: 2009-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the long-term effects of statins, atorvastatin, upon Nitric Oxide, as an endothelial function assessment, and C-Reactive Protein, an inflammatory marker, levels in patients with Peripheral Arterial Disease. These long-term biological pleiotropic effects of statins will offer information on the role of endothelial function and systemic inflammation in the etiopathogenesis of PAD.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Universitario Getafe
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• patients at the time of diagnosis of Fontaine grade II peripheral arterial disease (PAD), confirmed by hemodynamic evaluation (Doppler ultrasound)

• over 18 years old

Exclusion Criteria:

• patients had previously undergone revascularization

• patients were receiving treatment with statins

• patients with contraindications to statin use.

• patients with coexistence of chronic inflammatory diseases or steroidal medication