Overview

Long-term Versus Short-term Sequential Therapy (Intravenous Itraconazole Followed by Oral Solution) of Itraconazole as Primary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation

Status:
Unknown status

Trial end date:
2011-03-01

Target enrollment:

Participant gender:

Summary

- The primary objective of this study is to evaluate the efficacy and safety profile of itraconazole as in primary prophylaxis - The second objective of this study is to find the difference between long-term versus short-term sequential therapy of Itraconazole (intravenous followed by oral itraconazole) as primary prophylaxis of invasive fungal infections (IFI) in patients undergoing allogeneic stem cell transplantation (allo-SCT) - also to explore the relationship between the incidence of IFI with plasma concentrations of itraconazole and hydroxy-itraconazole

Phase:

Phase 2

Details

Lead Sponsor:

Guangzhou General Hospital of Guangzhou Military Command

Collaborators:

First Affiliated Hospital, Sun Yat-Sen University
Nanfang Hospital of Southern Medical University
Renmin Hospital of Zhongshan Guangdong
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Zhujiang Hospital

Treatments:

Hydroxyitraconazole
Itraconazole