Longitudinal Follow-up in Women With Endometrial Hyperplasia Without Atypia
Status:
Recruiting
Trial end date:
2026-01-29
Target enrollment:
Participant gender:
Summary
This study will prospectively enroll a total of 1000 patients (200 per year) simple
hyperplasia/complex hyperplasia (SH/CH) without atypia. All subjects will receive education
for exercise and weight control and be randomized 1:1 to with or without metformin
intervention. At the end of this 3-year project, an interim analysis will be performed. Since
long-term follow-up is intended, therefore for the 4th to 6th year a new grant support will
be looked for. The long-term occurrence of endometrial cancer (up to15 years) data will be
acquired from national cancer registry, which permission is addressed in the informed sent.