Longitudinal MR Imaging of Pulmonary Function in Patients Receiving Thoracic Radiation Treatment
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether magnetic resonance imaging (MRI) using
inhaled hyper polarized xenon-129 (129Xe) gas, and conventional contrast can help visualize
impaired lung function and detect changes over time in patients receiving treatment as well
as those who don't. 129Xe is a special type of xenon gas and when inhaled during MRI may be
able to show areas of abnormal thickening of parts of the lungs. These images combined with
images taken with injected contrast agents or other special types of MRI such as conventional
proton (1H) MRI may provide a better way to look at lung structure and function. The ultimate
goal is to predict the degree of radiation-induced lung injury that will develop in a given
patient for a given treatment plan. The investigators anticipate that these images will
provide more specific information about lung disease than standard lung function tests. The
use of 129Xe MRI is investigational. Investigational means that these tests have not yet been
approved by the US Food and Drug Administration and are only available in research studies
like this one. In addition, standard MRI with contrast is not typically done as standard of
care for monitoring changes due to thoracic radiation therapy, therefore, its use in this
study is also considered investigational.
Healthy volunteers are being asked to participate in this study because to develop a database
of functional images that are representative of healthy lungs.