Loop Diuretics in Chronic Kidney Disease

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to verify the efficacy of diuretic therapy on blood pressure control and left ventricular mass in patients affected by chronic kidney disease

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second University of Naples; University of Campania "Luigi Vanvitelli"
• Treatments: Diuretics; Furosemide; Sodium Potassium Chloride Symporter Inhibitors

Criteria

Inclusion Criteria:

• Chronic renal insufficiency in stage CKD 3 and 4 (GFR 60-15 ml/min/m2) estimated by Cockcroft-Gault formula corrected for body surface

• Systolic blood pressure >140 mmHg in treatment with at least 1 class of antihypertensive drugs

• Patients not in treatment from at least one month with loop diuretics

Exclusion Criteria:

• Loop diuretics treatment

• Variation of serum creatinine >30% in the last 3 months

• Steroid therapy and/or cytotoxic agents

• Edema syndromes (Nephrotic syndrome, cirrhosis, heart failure NYHA class 3 or 4)

• Neoplasia