Loratadine for the Reduction of G-CSF Induced Bone Pain in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization

• Status: Not yet recruiting
• Trial end date: 2021-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This early phase I trial studies how well loratadine works in reducing granulocyte-colony stimulating factor (G-CSF) induced bone pain in patients with multiple myeloma who are undergoing stem cell mobilization. Loratadine is an antihistamine that may help to reduce or control bone pain during the process of stem cell collection in patients with multiple myeloma.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rutgers, The State University of New Jersey
• Collaborator: National Cancer Institute (NCI)
• Treatments: Loratadine

Criteria

Inclusion Criteria:

• Patient must be able to provide informed consent

• Patients with confirmed diagnosis of multiple myeloma

• Able to swallow and retain oral medication

• All ethnic groups are eligible

Exclusion Criteria:

• Non-English speaking person

• Patients undergoing haploidentical allogeneic hematopoietic stem cell transplant

• Known allergies, hypersensitivity, or intolerance to any of the study medications, excipients, or similar compounds

• Any medical complications or conditions that would, in the investigator's judgement, interfere with full participation in the study

• On therapeutic dose of aspirin (doses greater than 81 mg) within 7 days prior to the start of the study