Overview

Lornoxicam vs. Paracetamol After Lower Abdominal Surgery

Status:
Completed

Trial end date:
2011-03-01

Target enrollment:
0

Participant gender:
All

Summary

Background: The aim of this prospective, randomized, double-blind study is to determine the most effective supplemental analgesic, paracetamol or lornoxicam for postoperative pain relief after lower abdominal surgery. Methods: Sixty patients scheduled for lower abdominal surgery under general anesthesia were randomly allocated to receive either isotonic saline (Control group), intravenous paracetamol 1 g every 6 h (Paracetamol group) or lornoxicam 16 mg then 8 mg after 12 h (Lornoxicam group). Additionally pain was treated postoperatively using morphine patient-controlled analgesia. Postoperative pain scores measured by the verbal pain score (VPS), morphine consumption and the incidence of side effects were measured at 1, 2, 4, 8, 12 and 24 hours postoperatively.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Dammam University

Treatments:

Acetaminophen
Lornoxicam
Piroxicam

Criteria

Inclusion Criteria:

- lower abdominal surgery

Exclusion Criteria:

- body weight more than 150% of their ideal body weight

- history of significant cardiac, pulmonary, renal, hepatic or hematological disease;
chronic drug or alcohol abuse; hypersensitivity to any of the studied drugs; bronchial
asthma; gastritis or peptic ulcer; and pregnancy

- patients who received any analgesic drug a day before surgery