Losartan and Memory

• Status: Completed
• Trial end date: 2022-03-31
• Target enrollment: 0
• Participant gender: All

Summary

This study investigates the effect of a single dose of 50mg losartan vs placebo on BOLD signal during memory encoding.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Treatments: Losartan

Criteria

Inclusion Criteria:

• willing and able to provide informed consent

• male or Female, aged 18-50 years

• body mass index (BMI) of 18-30 kg/m2

• non- or light-smoker (< 5 cigarettes a day)

• STAIT score of at least 40

Exclusion Criteria:

• Female participant who is pregnant or breast-feeding

• CNS-active medication during the last 6 weeks

• Current blood pressure or other heart medication (especially aliskiren or beta blockers)

• Diagnosis of intravascular fluid depletion or dehydration

• Past or present DSM-IV axis-I diagnosis or suspected diagnosis (from SCID results at screening)

• Alcohol or substance abuse

• First-degree family member with a history of a severe psychiatric disease

• Impaired liver or kidney function

• Lifetime history of epilepsy or other neurological disease, systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.

• High or moderate risk of coronavirus, based on the NHS checklist for coronavirus vulnerability https://www.nhs.uk/conditions/coronavirus-covid-19/people-at-higher-risk/whos-at-highe r-risk-from-coronavirus/

• Contraindication to MRI (e.g. metal implant)

• Insufficient English skills

• participated in another study involving CNS-active medication during the last 6 weeks Participants will also not be able to take part if they are left-handed, due to the research MRI aspect of the study relying on group means.