Low Dose Apomorphine and Parkinsonism

• Status: Withdrawn
• Trial end date: 2007-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if low doses of apomorphine worsen the motor symptoms of Parkinson's disease.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Oregon Health and Science University
• Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)
• Treatments: Apomorphine

Criteria

Inclusion Criteria:

• Have idiopathic Parkinson's disease treated with levodopa and experiencing motor fluctuations

• Response to levodopa had to be documented by a 10 percent increase in finger or foot tapping speed

Exclusion Criteria:

• Clinically significant cardiovascular, cerebrovascular, hepatic and renal diseases

• Psychosis

• Allergy to apomorphine or 5ht3 inhibitors

• Prolonged qt interval

• Pregnancy/breast-feeding

• Hemodynamic instability

• Severe nausea

• Alcohol/drug abuse

• Other unstable medical conditions