Low Dose Dexmedetomidine Versus Ketamine in Multiple Fracture Ribs

• Status: Recruiting
• Trial end date: 2021-12-25
• Target enrollment: 0
• Participant gender: All

Summary

In our study, we assess the diaphragmatic function, pain quality and anti-inflammatory properties between low dose infusion of dexmedetomidine and ketamine in patients with multiple fracture ribs on conservative treatment.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Dexmedetomidine; Ketamine

Criteria

Inclusion Criteria:

• Adults (age 18-65 years) of American Society of Anaesthesiologists (ASA) physical status I-II

• Traumatic multiple fracture ribs 3 ribs or more, who will be subjected to thorough assessments including chest 3D-CT

• Undergoing conservative treatment (chest strappings)

• Intractable pain with visual analogue scale (VAS) over 6 after traditional therapies

• Glasgow Coma Scale (GCS) ≥ 13.

Exclusion Criteria:

• Multiple traumas to body parts other than chest with an abbreviated injury scale over 3

• Serious head trauma with a Glasgow coma scale lower than 13

• Mechanically ventilated patients

• Massive hemothorax

• Injury to the trachea or bronchus with requirement for immediate surgery

• Dementia

• Use of corticosteroids during ICU stay

• Sepsis

• Continued use of neuromuscular blocking agents and aminoglycosides antibiotic use as they are known risk factors for ICU-acquired weakness and any known hypersensitivity

• Contraindication to the study drugs.