Low Dose Dexmedetomidine and Delirium After Cardiac Surgery
Status:
Completed
Trial end date:
2019-08-12
Target enrollment:
Participant gender:
Summary
Delirium after cardiac surgery can occur in up to 50% of the patients and has been shown to
be significantly associated with increased morbidity and mortality. Advanced age is a
significant risk factor of delirium.
Numerous studies have shown that sedation with high doses of Dexmedetomidine in the ICU
reduces the incidence of postoperative delirium. On the other hand animal studies have shown
neuroprotective effects of Dexmedetomidine by means of stimulating alpha2A-adrenoceptors.
It is not clear whether the administration of a low dose Dexmedetomidine in cardiac surgery
would have any neuroprotective effects by stimulating the alpha 2A-receptors and as such
would decrease the incidence of postoperative delirium.
Phase:
Phase 4
Details
Lead Sponsor:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain