Overview

Low Dose Fat-Induced Insulin Resistance

Status:
Recruiting
Trial end date:
2026-01-01
Target enrollment:
Participant gender:
Summary
The primary goal of this study is to determine the dose of fatty acids that acutely induces mild insulin resistance in healthy volunteers. We hypothesize that a low-dose of fatty acid infusion (Intralipid/heparin) will cause a mild insulin resistance. The dose of fatty acid infusion that reliably causes mild insulin resistance will be selected for use in future studies.
Phase:
Early Phase 1
Details
Lead Sponsor:
University of Pennsylvania
Treatments:
Insulin
Insulin, Globin Zinc
Soybean oil, phospholipid emulsion