Our previous studies have demonstrated that there is substantial metabolic opposition to the
maintenance of an altered body weight. Leptin is a protein secreted by fat cells and the
circulating concentrations of leptin are directly proportional to fat mass. Leptin-deficiency
is associated with severe obesity in rodents and in humans and the obesity is relieved by
leptin administration. These studies examine the hypothesis that some of this metabolic
opposition cto the maintenance of an altered body weight can be relieved by restoring
circulating concentrations of the hormone leptin to the same range as at usual body weight in
subjects who are maintaining a reduced body weight. The basic design of this study is to
observe subjects at a 10% reduced body weight and then again at that reduced body weight
while receiving physiological leptin or T3 supplementation.
Phase:
Phase 3
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)