Low Dose Magnesium Sulphate Versus Standard Pritchard Regimen In Management Of Severe Preeclampsia/Eclampsia
Status:
Completed
Trial end date:
2018-01-22
Target enrollment:
Participant gender:
Summary
Background - Preeclampsia/eclampsia, a pregnancy specific multi-systemic disease, is
associated with considerable maternal and perinatal morbidity and mortality. Prevention
and/or treatment of convulsion with magnesium sulphate, among others, is life-saving. Despite
different regimens that have been tried, the minimum effective dose of MgSO4 for the
prevention of eclampsia in patients with preeclampsia and treatment of convulsion in those
with eclampsia has not been determined.
Objectives - To compare the maternal and perinatal outcomes and maternal side effects in
eclamptic and preeclamptic participants treated with low dose regimen of MgSO4 with those
treated with the Pritchard regimen.
Materials and Methods - This will be a prospective, single blinded randomized controlled
study of low dose versus Pritchard regimens of MgSO4. Participants will be randomly assigned
to the either arm of the study. Efficacy and adverse effects of the drug on the mother and
baby will be noted. Data will be collated, tabulated and then statistically analysed using
the statistical package for social sciences (SPSS) Results - Conclusion will be drawn and
recommendation made from the findings in the study.