Low Dose of Sugammadex vs Neostigmine and Glycopyrrolate for the Reversal of Rocuronium

• Status: Recruiting
• Trial end date: 2023-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare the use of a low dose sugammadex and neostigmine combined to glycopyrrolate to reverse a rocuronium induced moderate neuromuscular blockade.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ciusss de L'Est de l'Île de Montréal
• Treatments: Glycopyrrolate; Neostigmine

Criteria

Inclusion Criteria:

• ASA 1-3 patients,

• Undergoing general anesthesia with rocuronium induced NMB,

• TOF 1-3 at the end of surgery,

• BMI < 36 kg.m-2,

• Age > 18 years old

Exclusion Criteria:

• History of coronary artery disease and unstable before surgery

• History of serious cardiac arrhythmia (including atrial fibrillation)

• Renal or hepatic dysfunction

• Obstructive sleep apnea requiring continuous positive airway pressure (CPAP) machine

• Neuromuscular disease

• Allergy to any drug used in the study protocol