Low Doses of Ketamine and Postoperative Quality of Recovery

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

There are evidences that intraoperative administration of low doses of ketamine may contribute to control the postoperative pain by acting on the N-methyl-D-aspartate (NMDA) channel, reducing the effects related to the tolerance and hyperalgesia induced by opioids. This study aims to evaluate the effects of administration of this agent not only as an analgesic but also its role in the quality of recovery from anesthesia, which includes observation of emotional, psychological and physical aspects. Patients who were scheduled to undergo total intravenous anesthesia (TIVA) for laparoscopic cholecystectomy will be enrolled in this clinical study. After induction of anesthesia, patients will receive one of three solutions according to the randomly selected group: ketamine 0,2 mg/kg; ketamine 0,4 mg/kg or saline. In the recovery room and on the ward, data related to the presence of pain, analgesic consumption, the incidence of nausea and vomiting, dizziness or hallucinations will be recorded. The next day, the quality of recovery will be evaluated by application of the questionnaire QoR40 (Quality of Recovery Questionnaire-40).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pontificia Universidade Catolica de Sao Paulo
• Treatments: Anesthetics; Ketamine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists physical status I or II

• Patients scheduled to undergo laparoscopic cholecystectomy

Exclusion Criteria:

• Patients who refuse to participate in the study

• Patients who are not able to communicate due to alterations in the level of consciousness, or neurologic, or psychiatric disease

• Contraindication of any of the drugs used in the study

• Patients who are superobese (BMI>40)

• History of alcohol or drug dependence