Low-chlorine Vs High-chlorine Crystalloids in Septic Shock Adults

• Status: Not yet recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Fluid resuscitation is an important treatment in septic shock patients, however whether crystalloid composition affects septic shock patients outcomes remains unclear. According to previous studies, low-chlorine crystalloids could significantly reduce the incidence of kidney injury and 30-day mortality compared with high-chlorine crystalloids in critically ill adults. Therefore, we hypothesized that the use of low-chlorine crystalloids would result in a lower incidence of major adverse kidney events within 30 days (MAKE 30: overall incidence of death, new renal-replacement therapy, and persistent renal dysfunction) than high-chlorine crystalloids in septic shock adults.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Southeast University, China

Criteria

Inclusion Criteria:

1. 18 years old2. Diagnosis of septic shock within 24 hours (sepsis 3.0);

3. Needing fluid resuscitation judged by clinicians;

4. The patient or the patient's legally acceptable representative signs the informed consent (signs within 24h of enrollment)

Exclusion Criteria:

1. Pregnant or lactating period;

2. Renal replacement therapy has been received or expected to receive within 6 hours;

3. Those who were previously enrolled in the study;

4. Estimated death within 24 hours;

5. Other situations that not suitable for enrollment judged by researchers.