Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients
Status:
Unknown status
Trial end date:
2021-04-30
Target enrollment:
Participant gender:
Summary
For patients undergoing mechanical ventilation, light sedation is better than deep sedation
for the outcomes, which is manifested as shortened length of ICU stay, shortened duration of
mechanical ventilation, and decreased mortality. In a recent study of the investigators,
low-dose dexmedetomidine without sedative effects (0.1 ug/kg/h) improved sleep quality and
reduced the incidence of delirium in elderly patients admitted to the ICU after surgery. The
investigators hypothesize that, for ICU patients with prolonged mechanical ventilation,
low-dose dexmedetomidine infusion (0.1 ug/kg/h) may also be effective in decreasing delirium.
The purpose of this study is to investigate whether low-dose dexmedetomidine infusion can
reduce the incidence of delirium in ICU patients with prolonged duration of mechanical
ventilation (>= 24 hours).