Low-dose Ketamine for Acute Pain in the Emergency Department

• Status: Unknown status
• Trial end date: 2017-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to determine the efficacy and safety of low dose ketamine in association with IV morphine in the management of acute moderate to severe pain in emergency department.

The investigators hypothesize that low dose ketamine will result in more effective pain control than morphine alone and will not be associated with an increase in adverse events.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Faculty of Medicine, Sousse
• Treatments: Ketamine; Morphine; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Able to understand and give informed consent

• Comfortable with the experimental protocol as outlined to them by the research team

• Severe pain, pain score of at least 50/100 on Visual Analogue Scale (VAS) or 5/10 numerical ratings score

• Acute pain, pain duration < 7days

• Deemed by treating ED attending physician to require IV opioid analgesia

Exclusion Criteria:

• Neurologic, respiratory, or hemodynamic compromise

• Pregnancy or breastfeeding

• Known or suspected allergy to ketamine or morphine

• Known Renal (Cr>2.0) or Liver Failure

• Unstable psychiatric disease (as per treating physician)

• History of stroke

• History of cardiac disease or coronary artery disease

• History of chronic respiratory disease