Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia
Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
Scoliosis correction surgery is followed with severe pain. Patients after scoliosis
correction surgery usually require high dose opioids and long duration analgesia, which may
increase side effects and even drug tolerance. S-ketamine is the pure dextrorotatory
enantiomer of ketamine with stronger analgesic effect and less side effects, but mental side
effects is a major concern. Dexmedetomidine can be used as an analgesic supplement; it also
improves sleep quality in postoperative patients. We hypothesize that low-dose ketamine and
dexmedetomidine in combination with opioids may have synergistic effect in analgesia and
reduce drug-related side effects. This study aims to explore the effect of low-dose of
S-ketamine and dexmedetomidine in combination with opioids for postoperative
patient-controlled intravenous analgesia in patients following scoliosis correction surgery.