Lower Limb Function After Spinal Cord Injury

• Status: Completed
• Trial end date: 2021-04-11
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, experimental study that examines the physiology of central nervous system pathways contributing to the control of bilateral movements in individuals with spinal cord injuries and promotes the recovery of lower-limb motor function through the use of stimulation and locomotor training.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Shirley Ryan AbilityLab; University of Miami
• Collaborator: The Craig H. Neilsen Foundation
• Treatments: Cycloserine

Criteria

Inclusion Criteria:

• 4. Inclusion criteria for individuals with SCI:

• Male and females between ages 18-85 years of age

• SCI ( ≥1 month of injury)

• ASIA A, B,C and D

• SCI above L5

• Able to perform a visible contraction with dorsiflexor and hip flexor muscles (allowing testing of largely impaired patients)

• Able to ambulate a few steps with or without an assistive device

Inclusion criteria for healthy controls:

• Male and females between ages 18-85 years of age

• Able to walk and complete lower-limb tests with both legs

Exclusion Criteria:

Exclusion criteria for individuals with SCI

• Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease,

• Any debilitating disease prior to the SCI that caused exercise intolerance

• Premorbid, ongoing major depression or psychosis, altered cognitive status

• History of head injury or stroke,

• Metal plate in skull

• History of seizures

• Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants.

• Pregnant females, and

• Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida or herniated cervical disk.

Exclusion criteria for healthy controls:

• Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease,

• Any debilitating disease that causes exercise intolerance

• Premorbid, ongoing major depression or psychosis, altered cognitive status

• History of head injury or stroke,

• Metal plate in skull

• History of seizures

• Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants.

• Pregnant females, and

• Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida or herniated cervical disk.