Lung Function Changes of Induced Asthma Children Treated With Inhaled MgSO4
Status:
Completed
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
As a non-selective bronchodilator, magnesium sulfate (MgSO4) is effective when administered
intravenously in the treatment of the patients with acute severe asthma not responding to
conventional therapy (oxygen, nebulized salbutamol, and corticosteroids), which can resulted
in earlier improvement in clinical signs and symptoms of asthma and PEF. However, the use of
intravenous MgSO4 administered is not common in clinical practice, because it's prone to have
adverse effects and side effects such as nausea, vomiting, facial flushing, hypotension,
decreased tendon reflexes and so on with this treatment. The aerosolised route offers the
advantage of lower dosage, a shorter time of drug being delivered to the airway smooth muscle
and lower incidence of side effects when compared to the intravenous route. At present, there
are only a few studies about the effects of nebulized MgSO4 in the treatment of acute asthma
in children, and the conclusions are controversial.