Luteal Phase Estradiol Support for In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles
Status:
Unknown status
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
Optimizing in vitro fertilization (IVF) success is more important than ever, in light of new
public funding of IVF in Ontario, Canada. In patients undergoing IVF using
gonadotropin-releasing hormone (GnRH) analogues, the luteal phase appears to be compromised,
which may be a result of controlled-ovarian hyperstimulation, significant fluctuations in
hormone levels, the impact of the oocyte retrieval process, or direct compromise of the
corpus luteum. Progesterone support is definitely necessary during the luteal phase to
facilitate implantation but whether estrogen supplementation is also needed remains unclear.
The present study aims to determine whether estradiol support during the luteal phase
improves clinical pregnancy rate in patients undergoing IVF.