Luteal Phase Progesterone in IUI and Gonadotropin Cycles
Status:
Unknown status
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
This is a study of patients undergoing Controlled Ovarian Hyperstimulation (COH) with
Gonadotropins and Intrauterine Insemination (IUI) at a Fertility Clinic.
Infertility is a common problem, and a popular method of therapy is to inject sperm through
the cervix and into the uterus, a procedure known as IUI. In conjunction with IUI, injectable
medications (gonadotropins) are used to stimulate the ovaries to produce more than one egg
per cycle in a process called COH.
Vaginal progesterone is used for luteal support in in vitro fertilization therapy and has
been proven to effect pregnancy rates. However, the role of progesterone in COH is still
unclear. In this study, the investigators want to examine the effect of giving vaginal
progesterone after COH with IUI on pregnancy rates. The investigators want to study if luteal
vaginal progesterone results in a higher pregnancy rate compared to no progesterone therapy
in COH with IUI. At present, fertility centres vary in the use of progesterone after
insemination, most likely due to the lack of studies on this subject.
At the Fertility Clinic all patients undergoing COH with injectable medications and IUI,
regardless of whether they are in the study, have a baseline transvaginal ultrasound and
blood tests. Patients start the injectable medications for COH until the ovarian follicles
are large enough, then a medication to release the eggs is given. The IUI is done
approximately 36 hours later. The day after the IUI, study patients will be given vaginal
progesterone while the control patients will receive no progesterone. All patients will be
followed until a pregnancy test is done and a viable foetus is confirmed by ultrasound.