Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates

• Status: Unknown status
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a single center, 3 arms, prospective randomized controlled open study to determine the impact of luteal phase support on pregnancy rates in ovarian stimulation and IUI cycles with recombinant FSH in patients with unexplained infertility and mild male factor.

Patients will be randomized into 3 groups:

1. Luteal support with progesterone only (they will received vaginal P gel (Crinone 8% vaginal gel; Serono, Israel)

2. Luteal support with estrogen + progesterone [(Crinone 8% vaginal gel; Serono, Israel) and Estrofem 4mg].

3. No luteal support

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rabin Medical Center
• Treatments: Estrogens; Progesterone

Criteria

Inclusion Criteria:

1. Couples with diagnosis of unexplained infertility

2. In their treatment cycle with ovarian stimulation and IUI using recombinant FSH in our institution.

Exclusion Criteria:

1. female partners with one or more of the following:

• previous ovarian surgery

• one ovary

• polycystic ovaries on ultrasound examination

• other endocrine abnormalities (i.e., polycystic ovarian syndrome, thyroid disorders,hyperprolactinemia,6.hypogonadotropic hypogonadism)

• past ovarian hyperstimulation or hyperstimulation during the study period

• diminished ovarian reserve (basal FSH level >15 IU/mL)

• age of >40 years

2. sever male factor < 5 million total motile sperm on the day of insemination.