Luteal Phase-start Ovarian Stimulation With Corifollitropin Alfa

• Status: Recruiting
• Trial end date: 2021-12-30
• Target enrollment: 0
• Participant gender: Female

Summary

To evaluate the effect of random-start of ovarian stimulation initiated in the early follicular or luteal phase on the pharmacokinetics and follicular dynamics and embryo euploidy rates in oocyte donors treated with identical ovarian stimulation protocols with corifollitropin alfa and GnRH antagonist pituitary downregulation

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Institut Universitari Dexeus

Criteria

Inclusion Criteria:

1. Healthy eligible oocyte donors

2. Age 18-34 years

3. AFC >12 and AMH>1.5 ng/ml

4. BMI 19-28kg/m2

5. Body weight >60kg

6. Both ovaries present

7. Willing to participate in the study

8. Willing to use non-hormonal contraception or not needing contraception Recipients will be eligible only if their partners' sperm which will be used for ICSI will be normal. Couples will be excluded in case of moderate to severe oligoasthenospermia.

Exclusion Criteria:

1. Endometriosis

2. AFC>20

3. PCOS

4. Low ovarian reserve

5. Endocrine abnormalities

6. Hormonal contraception

7. Contraindication of hormonal treatment

8. History of Ovarian Hyperstimulation Syndrome or hyper-response (> 30 follicles .

11mm)