Luteal Support in Frozen-Thawed Embryo Transfer Cycles

• Status: Not yet recruiting
• Trial end date: 2021-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study evaluates the clinical efficacy of 3 different luteal phase support in patients undergoing frozen-thawed embryo transfer cycles. Endometrium preparation will be hormone replacement in all cycles. Starting from day 11, group 1 will receive 100 mg micronized progesterone parenteral daily injections, group 2 will receive 90 mg bioadhesive gel vaginal twice daily and group 3 will receive 40 mg oral dydrogesterone daily tablets.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centrum Clinic IVF Center
• Treatments: Dydrogesterone; Progesterone

Criteria

Inclusion Criteria:

• woman aged 20-40 years

• Having available blastocyst(s) cryopreserved by vitrification method.

Exclusion Criteria:

• requirement for fresh embryo(s);

• presence of any clinically relevant systemic disease contraindicated for assisted reproduction or pregnancy

• history of more than three failed cycles of IVF

• history of recurrent abortions

• allergy history for relevant drugs

• body mass index of <18 or >38 kg/m2 at screening

• current breastfeeding or pregnancy

• refusal or inability to comply with the requirements of the protocol for any reason, including scheduled clinic visits and laboratory tests

• trophectoderm or blastomere biopsy of the blastocyst(s) to be transferred