Lycopene Following Aneurysmal Subarachnoid Haemorrhage

• Status: Unknown status
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study the investigators wish to explore the potential neuroprotective effects of acute oral supplementation of lycopene, a natural anti-oxidant derived from tomatoes, on cerebral vasospasm and autoregulation, and examine whether any improvements translate into a reduction of biochemical markers of vascular injury and inflammation a decrease in the prevalence of secondary strokes following subarachnoid haemorrhage.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Cambridge
• Collaborator: Cambridge Theranostics Ltd
• Treatments: Carotenoids; Lycopene

Criteria

Inclusion Criteria:

• Age: > 18 years old,

• Confirmed aneurysmal subarachnoid hemorrhage (aSAH),

• Time from ictus < 96 hours

Exclusion Criteria:

• Age: < 18 years old,

• Non-aneurysmal SAH,

• Time from ictus > 96 hours,

• Severe carotid atherosclerotic disease (≥70%)

• High-dose statin therapy (>80 mg/day fluvastatin; >40 mg/day simvastatin; >40 mg/day pravastatin; >10 mg/day atorvastatin; >10 mg/day rosuvastatin 28),

• Allergy or hypersensitivity to tomatoes and tomato products and history of any other significant atopy/allergy (e.g. soy, whey, lutein, lecithin)