Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment

• Status: Unknown status
• Trial end date: 2019-08-30
• Target enrollment: 0
• Participant gender: All

Summary

Periodontal diseases are among the most common medical conditions that may influence humans; 50% of the adult population can be affected by this illness. The condition is usually initiated by lack or reduction in oral hygiene which is then aggravated by the presence of microorganisms within biofilm which will induce a sequel of events that will lead to periodontitis. Scaling, root planning, and polishing (SRP) are the golden standard procedures in the treatment. Systemic antibiotics as adjunctive therapy has been established to be an excellent modality in controlling the bacterial virulence, hence, supporting the conventional SRP therapy. in order to avoid and limit the harmful effect of systemic antibiotics different locally applied preparations have been introduced including antioxidants. The aim of this prospective clinical study is to compare between the effect of Minocycline hydrochloride (HCL) microsphere and Lycopene gel when they are applied intrapocket subgingival with conventional SRP therapy

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Baghdad
• Treatments: Lycopene; Minocycline; TIMP1 protein, human; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinases

Criteria

Inclusion Criteria:

• Patients with chronic periodontitis with CAL ≥ 5 mm.

• No history of any systemic condition.

• Patient able to follow the required instructions.

• Willing to sign an informed consent form.

• Didn't receive any antibiotic therapy and periodontal therapy in the last 2-3 months.

Exclusion Criteria:

• Patients with systemic diseases that influence the condition (ex, hypertension, diabetes, kidney diseases and transplants).

• Patients who refuse to write an informed consent form.

• Smokers.

• Taking certain medications including antibiotics, antihypertensive, anticonvulsants, immunosuppressants, or any other drug that may affect the periodontal health status.

• Pregnant and lactating women.