Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment
Status:
Unknown status
Trial end date:
2019-08-30
Target enrollment:
Participant gender:
Summary
Periodontal diseases are among the most common medical conditions that may influence humans;
50% of the adult population can be affected by this illness. The condition is usually
initiated by lack or reduction in oral hygiene which is then aggravated by the presence of
microorganisms within biofilm which will induce a sequel of events that will lead to
periodontitis. Scaling, root planning, and polishing (SRP) are the golden standard procedures
in the treatment. Systemic antibiotics as adjunctive therapy has been established to be an
excellent modality in controlling the bacterial virulence, hence, supporting the conventional
SRP therapy. in order to avoid and limit the harmful effect of systemic antibiotics different
locally applied preparations have been introduced including antioxidants. The aim of this
prospective clinical study is to compare between the effect of Minocycline hydrochloride
(HCL) microsphere and Lycopene gel when they are applied intrapocket subgingival with
conventional SRP therapy
Phase:
Phase 2
Details
Lead Sponsor:
University of Baghdad
Treatments:
Lycopene Minocycline TIMP1 protein, human Tissue Inhibitor of Metalloproteinase-1 Tissue Inhibitor of Metalloproteinases