This is a randomized, open-label, two-way cross-over drug-drug interaction Phase I trial.
The objectives of this phase I trial are to investigate in healthy female subjects:
- the effect of prucalopride on the absorption of ethinylestradiol and norethisterone
acetate, the active constituents of several oral contraceptives, after the first dose of
prucalopride.
- the effect of multiple oral dosing of 2 mg prucalopride, for 6 days o.d. (steady state),
on the pharmacokinetics of ethinylestradiol and norethisterone acetate.
This trial will be conducted in healthy females of child bearing potential, i.e. females aged
between 18 and 45 years (pre-menopausal).