MD Ezetimibe Cyclosporine Interaction (0653-057)

• Status: Completed
• Trial end date: 2004-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Study to determine the effect of multiple oral doses of ezetimibe on the pharmacokinetics of a single oral dose cyclosporine in young healthy males and females.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Collaborator: Schering-Plough
• Treatments: Cyclosporine; Cyclosporins; Ezetimibe

Criteria

Inclusion Criteria:

• Subject is male or female between 18 to 45 years of age

• Subject is judged to be in good health on the basis of history, physical examination, and routine laboratory data

Exclusion Criteria:

• Premenopausal women who are currently pregnant or who are currently nursing

• Subjects with drug or substance abuse, poor mental function, history of major gastrointestinal abnormalities (stomach issues), or high cholesterol

• Subject that has donated blood or has participated in another clinical trial within the last four weeks