The pathogenesis of temporomandibular disorders focusing on the biochemistry of the synovial
fluid in various stages of temporomandibular joint disease. The role of inflammation has been
investigated and proposed as an underlying mechanism of pain and dysfunction of
temporomandibular joint. MESNA (sodium 2-mercaptoethanesulfonate) was approved several years
ago and marketed in several formulations as a mucolytic agent in the respiratory field, since
it breaks the disulfide bonds between polypeptide chains of mucus. The tissue distribution of
MESNA is negligible, and the elimination of the substance is rapidly and completely achieved
by kidney