MG Granules Improve COVID-19 Efficacy and Safety of Convalescent Exercise Tolerance

• Status: Not yet recruiting
• Trial end date: 2026-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The global coronavirus pandemic has infected nearly 659 million people and killed more than 6.6 million in the past three years. The symptoms of in-hospital recovery are long and difficult after epidemiological infection of 2019-NCo5. 76% of the 1,733 discharged patients in Wuhan in 2020 still had at least one symptom of discomfort 6 months after infection, with fatigue or muscle weakness being the most common (63%). Foreign Research: In the United States, 15 percent of 16,091 people infected with COVID-19 in 2021 had symptoms that persisted two months after infection. Novel Coronavirus Infection Diagnosis and Treatment Protocol (Trial 10th Edition) For patients recovering from novel coronavirus infection, TCM syndrome differentiation can be carried out according to the Guidelines for Home-based TCM Intervention for Patients Infected with Novel Coronavirus, and appropriate TCM prescriptions should be given for intervention.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Collaborators: Hangzhou Hospital of Traditional Chinese Medicine; Suzhou Hospital of Traditional Chinese Medicine; The First Affiliated Hospital of Zhejiang Chinese Medical University

Criteria

Inclusion Criteria:

1. Diagnostic criteria for convalestion-phase of COVID-19 patients: Patients with COVID-19 have entered the convalestion-phase when they meet any of the following criteria and other symptoms improve: 1) two consecutive negative nucleic acid tests with Ct values ≥35; 2) The antigen test results were negative for three consecutive days; 3) After staying at home for 7 days, the fever has subsided for more than 24 hours without using antipyretic drugs; (2) Middle-aged and elderly outpatients aged 50-80 (including 50 and 80 years old), regardless of gender; (3) The main clinical manifestations were fatigue, shortness of breath, cough (satisfying at least two main symptoms), and the results of 6-minute walking test were less than 80% of the predicted value (about 450-500 meters); Can be accompanied by poor puppie full, loose stool, light fat tongue, thin white or thin greasy moss, pulse floating, the performance of lung qi deficiency. (4) Voluntarily participate in this clinical study, give informed consent and sign informed consent.

Exclusion Criteria:

1. Severe and critically ill hospitalized patients with novel coronavirus infection; (2) accompanied by tumor, immune deficiency disease; (3) The researcher thinks that it is not appropriate to participate in this clinical research; (4) Suspected or confirmed history of alcohol and drug abuse; (5) Known or suspected allergic history to the study drug and its excipients; (6) participated in other clinical investigators within 3 months before screening; (7) Patients with severe neurological, cardiac, pulmonary, hematopoietic, endocrine, musculoskeletal motor system and other primary diseases and mental disorders; (8) Patients with clinical manifestations of Yin deficiency and fire flourishing (red tongue and thin pulse) or phlegm-dampness and lung stagnation (white and greasy moss, slippery pulse strings); (9) Life expectancy is less than 12 weeks due to underlying diseases.