MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
The objective of this clinical study is to evaluate the efficacy of multiple applications of
MI Varnish in combination with MI Paste Plus in caries protection and remineralization in
comparison to the use of a control (Crest 1,100ppm Fluoride tooth paste, Fluoride rinse
recommendation) in orthodontic patients in a randomized, single blind, prospective,
controlled clinical trial over 12 months.
The effect will be measured by white spot lesion regression and prevention as lesion count.
Lesions will be scored using the Enamel Decalcification Index (EDI) area evaluation scheme
(primary outcome), International Caries Detection and Assessment System (ICDAS), the caries
lesion activity criteria (Nyvad criteria; Bente Nyvad, Scandinavian Researcher), and
Quantitative Light Fluorescence (QLF, Inspektor Pro, Netherlands)/SOPROLIFE (SOPROLIFE
fluorescence camera system, Acteon, France) evaluation in maxillary and mandibular anterior
teeth with orthodontic brackets in treatment and control groups.