MK-0954E Study in Participants With Hypertension (MK-0954E-357)
Status:
Completed
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
This study is being done to evaluate the efficacy, safety, and tolerability of losartan
potassium 50 mg (L50) + hydrochlorothiazide 12.5 mg (H12.5) + amlodipine besylate 5 mg (A5)
(MK-0954E). The primary hypothesis is that L50/H12.5/A5 is more effective in lowering mean
trough sitting diastolic blood pressure (SiDBP) after 8 weeks of treatment compared to L50+A5
in Japanese participants with essential hypertension who are not adequately controlled
following an 8-week treatment with filter period study drug (L50+A5).