MRI in Finding Hypoxia in Patients Undergoing Chemo and Radiation for Head and Neck Cancer

• Status: Terminated
• Trial end date: 2012-07-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Diagnostic procedures, such as functional MRI, may help measure oxygen levels in tumor cells and may help in planning cancer treatment.

PURPOSE: This phase I trial is studying functional MRI to see how well it works in finding hypoxia in patients undergoing chemotherapy and radiation therapy for stage III or stage IV head and neck cancer.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Simmons Cancer Center; University of Texas Southwestern Medical Center

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed squamous cell carcinoma of the head and neck

• Stage III or IV disease

• Measurable disease

• Scheduled to undergo standard treatment including radiation therapy and chemotherapy

• Participation on study # 092004-010 for tissue procurement

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2

• Serum creatinine ≤ 1.5 OR creatinine clearance ≥ 40

• Body mass index ≤ 34 Kg/m^2

• Not claustrophobic

• No other contraindications to MRI (i.e., implanted pacemaker device)

• Not pregnant or nursing

• Negative pregnancy test

• No allergy to gadolinium

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics