MTZ Plus AMX in the Treatment of Smokers and Non-smokers

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Randomized controlled clinical trials have demonstrated that the use of amoxicillin (AMX) and metronidazole (MTZ) as adjuncts to mechanical therapy improves the clinical and microbiological outcomes of scaling and root planing (SRP) in non-smokers and smokers with ChP. However, the effects of this antibiotic protocol have not been directly compared in non-smokers and smokers. Therefore, the aim of this study will be to compare the clinical and microbiological effects of the adjunctive use of MTZ+AMX to SRP in smokers and non-smokers subjects with chronic periodontitis (ChP). It was hypothesized that non-smokers would benefit better from this combination of therapies than the smokers.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Guarulhos
• Treatments: Amoxicillin; Metronidazole

Criteria

Inclusion Criteria:

• Chronic periodontitis (AAP 1999);

• ≥35 years of age;

• Presence of at least 15 teeth;

• Minimum of 6 teeth with at least one site each with PD and clinical attachment level (CAL) ≥5 mm;

• At least 30% of the sites with PD and CAL ≥4 mm and bleeding on probing (BOP).

• Smokers: had smoked at least 10 cigarettes per day for a minimum of 5 years;

• Non-smokers: had never smoked.

Exclusion Criteria:

• Previous subgingival periodontal therapy;

• Pregnancy;

• Nursing;

• Systemic diseases that could affect the progression of periodontal disease (e.g. diabetes, osteoporosis);

• Long-term administration of anti - inflammatory medications;

• Need for antibiotic pre-medication for routine dental therapy;

• Continuous use of mouthrinses containing antimicrobials;

• Antibiotic therapy in the previous 6 months

• Allergy to MTZ or AMX.