Overview

MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty

Status:
Recruiting

Trial end date:
2024-02-01

Target enrollment:
0

Participant gender:
All

Summary

Compare the outcome following manipulation under anesthesia for stiffness in a randomized controlled fashion with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Outcomes will include pain, range of motion, as well as subjective outcome scores.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Mayo Clinic

Collaborator:

Knee Society

Treatments:

BB 1101
Celecoxib
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate

Criteria

Inclusion Criteria:

1. Subjects who have received a primary unilateral TKA for a diagnosis of osteoarthritis.

2. MUA's scheduled between 6-10 weeks postoperatively

Exclusion Criteria:

1. Intolerance to NSAIDs

2. Renal dysfunction

3. Age < 18 or > 90 years

4. Primary diagnosis of rheumatoid arthritis

5. Patients with a Glomerular Filtration Rate (GFR) <60 as the cut off for Chronic Kidney
Disease (CKD) (stage 3 CKD)