Magnesium Infusion for Pain Relief After Thoracotomy. A Randomized Controlled Trial.
Status:
Terminated
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
All patients were premedicated with oral midazolam 5-15 mg. one hour before surgery. General
anesthesia with double lumen endobronchial tube was given. Patient was induced by propofol
and fentanyl. Cisatracurium was given to facilitate intubation. Patient was ventilated with
50% oxygen in air. Anesthesia was maintained with propofol and fentanyl in order to keep
blood pressure and heart rate within 20% of the baseline. Cisatracurium was given every 30
minutes in order to control ventilation. At the end of surgery, neuromuscular blockade was
reversed.In PACU, the I.V. PCA machine was connected to the patient. The setting of PCA was
basal infusion of morphine 1 mg/hr bolus of morphine 1 mg with lockout interval 5 minutes and
4-hour limit 30 mg.The patient's mean arterial blood pressure, heart rate were recorded
before induction, before intubation, at 15, 15, 30, 60, 90 and 120 minutes after intubation,
and at 4, 8,16 and 24 h after surgery. The total amounts of fentanyl, propofol and magnesium
sulphate were recorded. The time between the cessation of magnesium sulphate and extubation
was recorded. The amounts of morphine usage at 4, 8, 16 and 24 hours after surgery were
recorded. Pain score was evaluated at rest and deep breath and sedation score at 1, 2, 3, 4,
8, 16 and 24 hours after surgery using numeric rating scale (NRS). Sedation score was graded
as 0 = fully awake, 1 = somnolence, responds to call, 2 = somnolence, responds to tactile
stimulation, 3 = asleep, responds to painful stimulation. The times that the patient first
sipping, taking food, sitting at the edge of bed and walk with help were also recorded. The
side effects such as nausea, vomiting, pruritus and respiratory depression were recorded.
Cost effective analysis was also evaluated.