Magnesium Replacement and Hyperglycemia After Kidney Transplantation
Status:
Recruiting
Trial end date:
2022-08-31
Target enrollment:
Participant gender:
Summary
The insulin receptor is dependent on magnesium and hypomagnesemia is associated with
increased insulin resistance and decreased insulin secretion and action. Recent data suggest
that hypomagnesemia may play a role in development of type 2 diabetes. Kidney transplantation
patients have low plasma magnesium levels, partly due to treatment with calcineurin
inhibitors. However, the role of magnesium in the development of post-transplant diabetes
mellitus (PTDM) is unclear.
The present study addresses, whether hypomagnesemia is feasible to reverse by oral
administration of magnesium.
The investigators wish to investigate whether oral magnesium supplementation is sufficient to
increase magnesium levels in kidney transplant recipients, and if supplementation improves
glycemic parameters as measured by an oral glucose tolerance test (OGTT).